Dermal penetration and modeling

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Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

This work models penetration enhancement by coupled diffusion processes for multiple substances. The macroscopic component is a model on the diffusion cell scale general theory and applications to dermal penetration. Chem. Eng. Sci., 66 (), pp. Google ScholarCited by: Oct 19,  · Keywords: percutaneous permeation, dermal delivery, transdermal, bioequivalence, ex vivo skin models, reconstructed skin Introduction The skin is a major physical, immunological, and sensory barrier to our by:

Skin models for the testing of transdermal drugs

To further characterise the EpiDerm tissue for potential use in genotoxicity testing, we have evaluated the dermal penetration and metabolism of two hair dye ingredients, p-aminophenol (PAP) and p-phenylenediamine (PPD) in this reconstructed epidermis model. Home / MAPP / Toxicity Endpoints & Tests / Dermal Penetration / Dermal – Emerging Science & Policy. Toxicity Testing Overview. Validation, Regulatory Acceptance & International Harmonization; Detailed modeling of skin penetration–an overview. Adv. Drug Deliv. Rev. 65(2),
Evaluation of skin absorption of drugs from topical and transdermal formulations AUBÖCK, J.; WOLZT, M.; VALENTA, C. In vitro vs. in vivo tape stripping: Validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. LUCOVÁ, M. Dermal absorption and hydrolysis of methylparaben in different vehicles Cited by: Reconstituted 3D skin and (Q)SAR models for dermal penetration testing are covered further in the Emerging Science & Policy section. Global Acceptance of the In Vitro Test Guideline OECD In vitro dermal penetration methods that utilize resected human.
the potential for PFOA dermal absorption. Since the potential for PFOA dermal exposure exists not only in occupationally exposed adults but also in adult consumers and children, it is important to fully understand the potential for dermal penetration and the risk of exposure to PFOA through the dermal route. Understanding and modeling the disposi-. Health Effects Test Guidelines OPPTS Dermal Penetration: I: intended as a model of absorption through the human skin but rather as a test system for dermal absorption. It is possible to use the absorption OPPTS - Dermal Penetration.
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